Your truck should already have the 4:10 gears. Your best bang for the buck would be a ProCharger system. Not cheap, but their kits are complete. You'd get about 150 hp over stock, no bottom end mods are necessary, and at a low 7 psi of boost. On their link they have a kit for your 2000 6.0 truck.
https://www.procharger.com/
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2019 Keystone Montana 3560RL, 2020 Chevy 2500 HD, Firestone airbags, Air Lift wireless compressor, Curt gooseneck, 20K Reese Goosebox, TST-507, USMC combat vet & retired LEO. Robert, Anika, Breanna, Dylan (daughter-in-law Stephanie). & our Great Pyrenees Layla
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