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If you think the section of I-40 between Asheville and Knoxville is bad; try the section between Asheville and Hickory! I've never pulled my rig across there but driven in car numerous times. Anytime you see the emergency run off ramp sand traps every half mile or so tells you it's steep.
I'm not that familiar with I-77, but the stretch of I-64 between Charleston and Lexington isn't bad at all. As far as ongoing road construction, most states have pretty accurate information on their DOT websites.
Have you chosen a campground in the Lexington area yet? I live in the area and can tell you there are a couple that have a grossly overrated internet rating. One of the highest rated parks on Good Sam Club is accessed by a very narrow 2 lane road with no shoulders and big drop offs. This road is also the access to the county landfill and there are large trucks traveling there pretty constantly. Let me know if I can help.
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